Title : Transient kinetic studies on the interaction of Ras and the Ras-binding domain of c-Raf-1 reveal rapid equilibration of the complex.

Pub. Date : 1998 Oct 6

PMID : 9760267






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The GDP complex of H-Ras binds more than 2 orders of magnitude more weakly than the GTP-analogue complex, mainly due to a significant weakening of the initial binding equilibrium reaction in the GDP state, thereby avoiding even short-lived recruitment of Raf to the plasma membrane by the inactive Ras form. Guanosine Diphosphate HRas proto-oncogene, GTPase Homo sapiens
2 The GDP complex of H-Ras binds more than 2 orders of magnitude more weakly than the GTP-analogue complex, mainly due to a significant weakening of the initial binding equilibrium reaction in the GDP state, thereby avoiding even short-lived recruitment of Raf to the plasma membrane by the inactive Ras form. Guanosine Diphosphate HRas proto-oncogene, GTPase Homo sapiens