Title : Chronic infusion of adrenomedullin reduces pulmonary hypertension and lessens right ventricular hypertrophy in rats administered monocrotaline.

Pub. Date : 1998 Aug 14

PMID : 9754936






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1 Chronic infusion of adrenomedullin reduces pulmonary hypertension and lessens right ventricular hypertrophy in rats administered monocrotaline. Monocrotaline adrenomedullin Rattus norvegicus
2 We investigated whether the chronic infusion of rat adrenomedullin would affect pulmonary hypertension and right ventricular hypertrophy produced by the administration of monocrotaline. Monocrotaline adrenomedullin Rattus norvegicus
3 Chronic infusion of adrenomedullin significantly lessened the increase in right ventricular systolic pressure and the ratio of right ventricular weight to body weight seen after monocrotaline treatment. Monocrotaline adrenomedullin Rattus norvegicus
4 These results suggest that chronic infusion of adrenomedullin attenuates the pulmonary hypertension and right ventricular hypertrophy seen in rats treated with monocrotaline. Monocrotaline adrenomedullin Rattus norvegicus