Title : IFN-gamma-induced iNOS mRNA expression is inhibited by rebamipide in murine macrophage RAW264.7 cells.

Pub. Date : 1998 Sep

PMID : 9753237






3 Functional Relationships(s)
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1 NO production was stimulated by IFN-gamma, and the level was attenuated by rebamipide in a dose-dependent manner. rebamipide interferon gamma Mus musculus
2 In a cell-free system, rebamipide did not affect iNOS enzyme activity; however, rebamipide inhibited iNOS mRNA and protein expression induced by IFN-gamma. rebamipide interferon gamma Mus musculus
3 Thus, we concluded that rebamipide inhibited IFN-gamma-induced NO production as a result of its inhibitory action on iNOS mRNA expression. rebamipide interferon gamma Mus musculus