Title : Essential role of p53 in phenethyl isothiocyanate-induced apoptosis.

Pub. Date : 1998 Sep 15

PMID : 9751619






6 Functional Relationships(s)
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1 Essential role of p53 in phenethyl isothiocyanate-induced apoptosis. phenethyl isothiocyanate tumor protein p53 Homo sapiens
2 This was demonstrated not only by results that PEITC induction of p53 protein expression and p53-dependent transactivation but also by PEITC-induced apoptosis in p53 +/+ cells but not in p53 -/- cells. phenethyl isothiocyanate tumor protein p53 Homo sapiens
3 This was demonstrated not only by results that PEITC induction of p53 protein expression and p53-dependent transactivation but also by PEITC-induced apoptosis in p53 +/+ cells but not in p53 -/- cells. phenethyl isothiocyanate tumor protein p53 Homo sapiens
4 This was demonstrated not only by results that PEITC induction of p53 protein expression and p53-dependent transactivation but also by PEITC-induced apoptosis in p53 +/+ cells but not in p53 -/- cells. phenethyl isothiocyanate tumor protein p53 Homo sapiens
5 This was demonstrated not only by results that PEITC induction of p53 protein expression and p53-dependent transactivation but also by PEITC-induced apoptosis in p53 +/+ cells but not in p53 -/- cells. phenethyl isothiocyanate tumor protein p53 Homo sapiens
6 Our results demonstrate for the first time that p53 elevation is required for PEITC-induced apoptosis, which may be involved in its cancer chemopreventive activity. phenethyl isothiocyanate tumor protein p53 Homo sapiens