Title : Intracellular acidosis differentially regulates KV channels in coronary and pulmonary vascular muscle.

Pub. Date : 1998 Oct

PMID : 9746485






2 Functional Relationships(s)
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1 In patch-clamp studies, whole cell K+ currents were elicited by 10-mV depolarizing steps between -60 and 0 mV in VSM cells obtained from 50- to 150-micrometers-OD arterial branches, and pHi was lowered by altering the NH4Cl gradient across the cell membrane. Ammonium Chloride glucose-6-phosphate isomerase Rattus norvegicus
2 These changes were reversed by returning cells to the control pHi of 7.0 and were eliminated by dialyzing cells with pipette solution containing 50 mmol/l HEPES to buffer NH4Cl-induced changes in pHi. Ammonium Chloride glucose-6-phosphate isomerase Rattus norvegicus