Title : Treatment of normal skeletal muscle with FK506 or rapamycin results in halothane-induced muscle contracture.

Pub. Date : 1998 Sep

PMID : 9743407






1 Functional Relationships(s)
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1 This finding suggests that a mutation in FKBP12 or changes in its capacity to bind to the ryanodine receptor could alter the halothane sensitivity of the skeletal muscle ryanodine receptor and thereby predispose the person to malignant hyperthermia. Halothane ryanodine receptor 1 Homo sapiens