Pub. Date : 1998 Sep 15
PMID : 9736628
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We found that both MuB-ADP and MuB-ATP stimulate transposase, whereas only MuB-ATP binds with high affinity to DNA. | Adenosine Triphosphate | ubiquitin like 3 | Homo sapiens |
| 2 | We found that both MuB-ADP and MuB-ATP stimulate transposase, whereas only MuB-ATP binds with high affinity to DNA. | Adenosine Triphosphate | ubiquitin like 3 | Homo sapiens |
| 3 | Four different ATPase-defective MuB mutants fail to activate the normal transposition pathway, further indicating that ATP plays critical regulatory roles during transposition. | Adenosine Triphosphate | ubiquitin like 3 | Homo sapiens |
| 4 | Based on these studies, we propose that the switch from the ATP- to ADP-bound form allows MuB to release the target DNA while maintaining its stimulatory interaction with transposase. | Adenosine Triphosphate | ubiquitin like 3 | Homo sapiens |
| 5 | Thus, ATP-hydrolysis by MuB appears to function as a molecular switch controlling how target DNA is delivered to the core transposition machinery. | Adenosine Triphosphate | ubiquitin like 3 | Homo sapiens |