Title : Docetaxel chronopharmacology in mice.

Pub. Date : 1998 Sep 1

PMID : 9731500






2 Functional Relationships(s)
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1 Docetaxel increased the median survival of tumor-bearing mice in a dose-dependent manner (controls: 24 days; 20 mg/kg weekly, 33 days; 30 mg/kg weekly or day 1, 3, 5 schedule, 44 or 46 days, respectively; Exp 5-7). Docetaxel exportin 5 Mus musculus
2 In Exp 5 and 6, the percentage of increase in life span was largest if docetaxel was administered weekly at 7 HALO (20 mg/kg, 220%; 30 mg/kg, 372%) and lowest after docetaxel dosing at 19 HALO (80% with 20 mg/kg) or at 15 HALO (78% with 30 mg/kg). Docetaxel exportin 5 Mus musculus