Title : Beta-receptor blockade decreases carnitine palmitoyl transferase I activity in dogs with heart failure.

Pub. Date : 1998 Jun

PMID : 9730105






2 Functional Relationships(s)
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1 BACKGROUND: Pharmacological inhibition of carnitine palmitoyl transferase I (CPT-I), the enzyme controlling the rate of fatty acid transport into the mitochondria, prevents the contractile dysfunction, myosin isozyme shift and deterioration in sarcoplasmic reticulum Ca2+ handling that occurs in rat models of left ventricular hypertrophy. Fatty Acids carnitine palmitoyltransferase 1B Rattus norvegicus
2 BACKGROUND: Pharmacological inhibition of carnitine palmitoyl transferase I (CPT-I), the enzyme controlling the rate of fatty acid transport into the mitochondria, prevents the contractile dysfunction, myosin isozyme shift and deterioration in sarcoplasmic reticulum Ca2+ handling that occurs in rat models of left ventricular hypertrophy. Fatty Acids carnitine palmitoyltransferase 1B Rattus norvegicus