Title : Beta-receptor blockade decreases carnitine palmitoyl transferase I activity in dogs with heart failure.

Pub. Date : 1998 Jun

PMID : 9730105






2 Functional Relationships(s)
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1 Dogs treated with metoprolol had a marked decrease in CPT-I activity (0.46 +/- 0.03 vs. 0.64 +/- 0.02 micromol min(-1) g(-1) wet weight; P < .02) along with an increase in triglyceride concentration compared to untreated heart failure dogs (3.9 +/- 0.3 v 4.9 +/- 0.2 micromol/g wet weight, respectively; P < .003). Metoprolol carnitine palmitoyltransferase 1B Rattus norvegicus
2 CONCLUSION: Metoprolol induced a decrease in CPT-I activity and an increase in triglyceride content. Metoprolol carnitine palmitoyltransferase 1B Rattus norvegicus