Pub. Date : 1998 Sep 1
PMID : 9724550
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Arginine-42 and threonine-45 are required for FAD incorporation and catalytic activity in human monoamine oxidase B. | Flavin-Adenine Dinucleotide | monoamine oxidase B | Homo sapiens |
2 | The oxidation of these amine substrates requires the cofactor FAD, which is covalently bound to Cys-397 of human MAO B. | Flavin-Adenine Dinucleotide | monoamine oxidase B | Homo sapiens |
3 | Previously, Glu-34 and Tyr-44 of MAO B have been identified as residues which engage in noncovalent interactions with FAD that are required for subsequent covalent FAD binding and generation of catalytic activity. | Flavin-Adenine Dinucleotide | monoamine oxidase B | Homo sapiens |
4 | Previously, Glu-34 and Tyr-44 of MAO B have been identified as residues which engage in noncovalent interactions with FAD that are required for subsequent covalent FAD binding and generation of catalytic activity. | Flavin-Adenine Dinucleotide | monoamine oxidase B | Homo sapiens |
5 | However, conservative substitutions of Arg-42 with lysine or Thr-45 with serine resulted in MAO B variants that retain both partial activity and partial FAD incorporation. | Flavin-Adenine Dinucleotide | monoamine oxidase B | Homo sapiens |
6 | These results indicate that Arg-42 and Thr-45 form critical noncovalent interactions with FAD that are required for the subsequent activation of MAO B by covalent coupling of FAD. | Flavin-Adenine Dinucleotide | monoamine oxidase B | Homo sapiens |
7 | These results indicate that Arg-42 and Thr-45 form critical noncovalent interactions with FAD that are required for the subsequent activation of MAO B by covalent coupling of FAD. | Flavin-Adenine Dinucleotide | monoamine oxidase B | Homo sapiens |