Pub. Date : 1998 Sep 4
PMID : 9722602
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, the potential for regulation of this novel TGF-beta1-activated oxidase in fibroblasts by protein tyrosine phosphorylation was examined. | Tyrosine | transforming growth factor beta 1 | Homo sapiens |
| 2 | The protein-tyrosine kinase inhibitors genistein and herbimycin A inhibited TGF-beta1-induced protein tyrosine phosphorylation, NADH oxidase activation, and H2O2 production in a dose-dependent manner. | Tyrosine | transforming growth factor beta 1 | Homo sapiens |
| 3 | These results suggest that protein tyrosine phosphorylation by a nonreceptor protein-tyrosine kinase(s) regulates the activity of the TGF-beta1-responsive H2O2-generating NADH oxidase in human lung fibroblasts. | Tyrosine | transforming growth factor beta 1 | Homo sapiens |
| 4 | Additionally, this study demonstrates that TGF-beta1, which binds to a serine-threonine kinase receptor, is able to induce protein tyrosine phosphorylation in a delayed manner via a signaling pathway that requires transcriptional activation. | Tyrosine | transforming growth factor beta 1 | Homo sapiens |