Title : The effect of PDGF, TGF-beta and IGF in combination on androgen metabolism by fibroblasts.

Pub. Date : 1998 Aug

PMID : 9722268






3 Functional Relationships(s)
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1 Similarly, PDGF/TGF-beta resulted in a 2-fold increase in DHT synthesis over controls (n=5; p<0.01) which compared with individual PDGF incubations, and the TGF-beta/IGF combination resulted in a 30% increase in DHT synthesis over controls (n=3; p<0.01); this was less than the 2.8/2.5-fold increases produced individually. Dihydrotestosterone transforming growth factor beta 1 Homo sapiens
2 Similarly, PDGF/TGF-beta resulted in a 2-fold increase in DHT synthesis over controls (n=5; p<0.01) which compared with individual PDGF incubations, and the TGF-beta/IGF combination resulted in a 30% increase in DHT synthesis over controls (n=3; p<0.01); this was less than the 2.8/2.5-fold increases produced individually. Dihydrotestosterone transforming growth factor beta 1 Homo sapiens
3 Similarly, when 14C-4-androstenedione was used as the substrate, there were 2-fold increases in DHT synthesis in response to combinations of PDGF/IGF and PDGF/TGF-beta (n=5; p<0.01). Dihydrotestosterone transforming growth factor beta 1 Homo sapiens