Title : Induction of an ATPase inhibitor protein by propylthiouracil and protection against paracetamol (acetaminophen) hepatotoxicity in the rat.

Pub. Date : 1998 Jul

PMID : 9720771






3 Functional Relationships(s)
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1 The purpose of the present study was to test the following hypothesis: propylthiouracil (PTU) treatments of rats induces an increase in the concentration and activity of the mitochondrial ATPase (m-ATPase) inhibitor protein (IF1). Propylthiouracil ATP synthase inhibitory factor subunit 1 Rattus norvegicus
2 The purpose of the present study was to test the following hypothesis: propylthiouracil (PTU) treatments of rats induces an increase in the concentration and activity of the mitochondrial ATPase (m-ATPase) inhibitor protein (IF1). Propylthiouracil ATP synthase inhibitory factor subunit 1 Rattus norvegicus
3 Propylthiouracil pretreatment for 12 days enhanced the concentration of the following metabolites in the liver: ATP (1.5 fold), ATPase inhibitor protein (IF1) (4.5 fold), and reduced glutathione (1.3 fold), while the activity of the inhibitor protein increased 2 fold. Propylthiouracil ATP synthase inhibitory factor subunit 1 Rattus norvegicus