Title : Induction of DNA damage, inhibition of DNA synthesis, and suppression of c-myc expression by the topoisomerase I inhibitor, camptothecin, in MCF-7 human breast tumor cells.

Pub. Date : 1998 Apr 15

PMID : 9719482






3 Functional Relationships(s)
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1 Induction of DNA damage, inhibition of DNA synthesis, and suppression of c-myc expression by the topoisomerase I inhibitor, camptothecin, in MCF-7 human breast tumor cells. Camptothecin MYC proto-oncogene, bHLH transcription factor Homo sapiens
2 At camptothecin concentrations of 5, 10, and 25 microM, where suppression of c-myc expression was observed, strand breaks in bulk DNA were also detected. Camptothecin MYC proto-oncogene, bHLH transcription factor Homo sapiens
3 In contrast to the absence of detectable damage to bulk DNA or suppression of c-myc expression at the lower concentrations of camptothecin, DNA synthesis was inhibited over the entire range of drug concentrations and demonstrated a strong correspondence with growth inhibition. Camptothecin MYC proto-oncogene, bHLH transcription factor Homo sapiens