Pub. Date : 1998 Apr 15
PMID : 9719482
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Induction of DNA damage, inhibition of DNA synthesis, and suppression of c-myc expression by the topoisomerase I inhibitor, camptothecin, in MCF-7 human breast tumor cells. | Camptothecin | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
2 | At camptothecin concentrations of 5, 10, and 25 microM, where suppression of c-myc expression was observed, strand breaks in bulk DNA were also detected. | Camptothecin | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
3 | In contrast to the absence of detectable damage to bulk DNA or suppression of c-myc expression at the lower concentrations of camptothecin, DNA synthesis was inhibited over the entire range of drug concentrations and demonstrated a strong correspondence with growth inhibition. | Camptothecin | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |