Title : The inhibitory effect of interleukin 1beta on rat hepatocyte DNA synthesis is mediated by nitric oxide.

Pub. Date : 1998 Aug

PMID : 9696008






2 Functional Relationships(s)
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1 We also found that hepatocyte DNA synthesis inhibition by IL-1beta was completely antagonized by providing deoxynucleosides to bypass the block in ribonucleotide reductase, a rate-limiting step in DNA synthesis, thus implicating this enzyme in the mechanism of growth inhibition by IL-1beta. deoxynucleosides interleukin 1 beta Rattus norvegicus
2 We also found that hepatocyte DNA synthesis inhibition by IL-1beta was completely antagonized by providing deoxynucleosides to bypass the block in ribonucleotide reductase, a rate-limiting step in DNA synthesis, thus implicating this enzyme in the mechanism of growth inhibition by IL-1beta. deoxynucleosides interleukin 1 beta Rattus norvegicus