Title : Oleate potentiates oxysterol inhibition of transcription from sterol regulatory element-1-regulated promoters and maturation of sterol regulatory element-binding proteins.

Pub. Date : 1998 Aug 14

PMID : 9694903






5 Functional Relationships(s)
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1 Our data indicate that C18 fatty acids can potentiate the biological activities of a typical, regulatory sterol: 25-hydroxycholesterol. 25-hydroxycholesterol Bardet-Biedl syndrome 9 Homo sapiens
2 Inhibition of C18 fatty acid synthesis in cells cultured in serum-free medium renders them resistant to killing by 25-hydroxycholesterol. 25-hydroxycholesterol Bardet-Biedl syndrome 9 Homo sapiens
3 Repression of expression of reporter constructs driven by promoters bearing SRE-1 element(s) by 25-hydroxycholesterol is increased by C18 fatty acid supplementation. 25-hydroxycholesterol Bardet-Biedl syndrome 9 Homo sapiens
4 C18 fatty acids also increase the inhibitory effect of 25-hydroxycholesterol on proteolytic maturation and nuclear localization of SREBPs. 25-hydroxycholesterol Bardet-Biedl syndrome 9 Homo sapiens
5 Furthermore, we also show that C18 fatty acid supplementation can enhance the inhibitory effect of 25-hydroxycholesterol on sterol and fatty acid biosynthesis. 25-hydroxycholesterol Bardet-Biedl syndrome 9 Homo sapiens