Title : Phorbol ester-induced transcription of a fibroblast growth factor-binding protein is modulated by a complex interplay of positive and negative regulatory promoter elements.

Pub. Date : 1998 Jul 24

PMID : 9668098






3 Functional Relationships(s)
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Protein Name
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1 Further mutational analysis revealed that full TPA induction required interplay between several regulatory elements with homology to Ets, AP-1, and CAATT/enhancer binding protein C/EBP sites. Tetradecanoylphorbol Acetate JunB proto-oncogene, AP-1 transcription factor subunit Homo sapiens
2 In addition, deletion or mutation of a 10-base pair region juxtaposed to the AP-1 site dramatically increased TPA induced FGF-BP gene expression. Tetradecanoylphorbol Acetate JunB proto-oncogene, AP-1 transcription factor subunit Homo sapiens
3 Gel shift analysis showed specific and TPA-inducible protein binding to the Ets, AP-1, and C/EBP sites. Tetradecanoylphorbol Acetate JunB proto-oncogene, AP-1 transcription factor subunit Homo sapiens