Pub. Date : 1998 Jun
PMID : 9667752
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | N-Methyl-N"-nitro-nitrosoguanidine and N-ethyl-N-nitrosourea, two direct-acting genotoxic (DNA-reactive) carcinogens, caused p53 induction as early as 2 h following treatment, with peak increases within 4-12 h. Aflatoxin B1 and 2-acetylaminofluorene, indirect-acting genotoxic carcinogens, caused a later induction of p53, with the peak increase appearing between 16 and 24 h following treatment. | Ethylnitrosourea | tumor protein p53 | Homo sapiens |
| 2 | N-Methyl-N"-nitro-nitrosoguanidine and N-ethyl-N-nitrosourea, two direct-acting genotoxic (DNA-reactive) carcinogens, caused p53 induction as early as 2 h following treatment, with peak increases within 4-12 h. Aflatoxin B1 and 2-acetylaminofluorene, indirect-acting genotoxic carcinogens, caused a later induction of p53, with the peak increase appearing between 16 and 24 h following treatment. | Ethylnitrosourea | tumor protein p53 | Homo sapiens |