Title : Contribution of rpoB mutations to development of rifamycin cross-resistance in Mycobacterium tuberculosis.

Pub. Date : 1998 Jul

PMID : 9661035






1 Functional Relationships(s)
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1 The contributions of 23 insertion, deletion, or missense mutations within an 81-bp fragment of rpoB, the gene encoding the beta-subunit of the DNA-dependent RNA polymerase of Mycobacterium tuberculosis, to the development of resistance to rifamycins (rifampin, rifabutin, rifapentine, and KRM-1648) in 29 rifampin-resistant clinical isolates were defined. KRM 1648 DNA-directed RNA polymerase subunit beta Mycobacterium tuberculosis H37Rv