Pub. Date : 1998 Aug
PMID : 9648916
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Treatment with 1-10 microM CD resulted in an increased 1) incidence of rounded cells, 2) relative PAI-1 mRNA content, and 3) fraction of PAI-1 protein-expressing cells. | Cytochalasin D | serpin family E member 2 | Rattus norvegicus |
| 2 | Treatment with 1-10 microM CD resulted in an increased 1) incidence of rounded cells, 2) relative PAI-1 mRNA content, and 3) fraction of PAI-1 protein-expressing cells. | Cytochalasin D | serpin family E member 2 | Rattus norvegicus |
| 3 | Maximal levels of induced PAI-1 transcripts (18-fold that of control) occurred 4 hours post-CD addition and declined thereafter but remained elevated (by at least tenfold) for 24 hours. | Cytochalasin D | serpin family E member 2 | Rattus norvegicus |
| 4 | Assessment of the metabolic requirements for CD-induced PAI-1 expression by using the protein synthesis inhibitors puromycin and cycloheximide indicated that PAI-1 transcripts were regulated in a complex manner in response to CD. | Cytochalasin D | serpin family E member 2 | Rattus norvegicus |
| 5 | Assessment of the metabolic requirements for CD-induced PAI-1 expression by using the protein synthesis inhibitors puromycin and cycloheximide indicated that PAI-1 transcripts were regulated in a complex manner in response to CD. | Cytochalasin D | serpin family E member 2 | Rattus norvegicus |
| 6 | Assessment of the metabolic requirements for CD-induced PAI-1 expression by using the protein synthesis inhibitors puromycin and cycloheximide indicated that PAI-1 transcripts were regulated in a complex manner in response to CD. | Cytochalasin D | serpin family E member 2 | Rattus norvegicus |
| 7 | Assessment of the metabolic requirements for CD-induced PAI-1 expression by using the protein synthesis inhibitors puromycin and cycloheximide indicated that PAI-1 transcripts were regulated in a complex manner in response to CD. | Cytochalasin D | serpin family E member 2 | Rattus norvegicus |
| 8 | Relative abundance of PAI-1 transcripts in suspended cells cultured in the presence of CD, however, closely approximated that of plastic-adherent, CD-treated cells (13-fold over control). | Cytochalasin D | serpin family E member 2 | Rattus norvegicus |
| 9 | A protein tyrosine kinase is likely involved in the CD-mediated signal-transduction cascade, since induced PAI-1 expression can be down-regulated by genistein and herbimycin A but not by calphostin C or tyrphostin B46. | Cytochalasin D | serpin family E member 2 | Rattus norvegicus |