Title : Microsatellite instability and frameshift mutations in BAX and transforming growth factor-beta RII genes are very uncommon in acute lymphoblastic leukemia in vivo but not in cell lines.

Pub. Date : 1998 Jul 1

PMID : 9639521






2 Functional Relationships(s)
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1 This instability is reflected in a high mutation rate of microsatellites, and recent studies in colon cancer indicate that defects in MMR result in frequent frameshift mutations in mononucleotide repeats located in the coding regions of BAX and transforming growth factor-beta (TGF-beta) receptor genes. mononucleotide BCL2 associated X, apoptosis regulator Homo sapiens
2 Microsatellite markers were compared between blast and normal DNA from the same patients and mutations were sought in mononucleotide repeat sequences of BAX and TGF-beta receptor II (TGF-beta RII). mononucleotide BCL2 associated X, apoptosis regulator Homo sapiens