Title : An intrinsically stable antibody scFv fragment can tolerate the loss of both disulfide bonds and fold correctly.

Pub. Date : 1998 May 15

PMID : 9637257






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 A fully functional cysteine-free derivative of the intrinsically stable anti-HER2 scFv fragment hu4D5-8 was generated by replacing the disulfide forming cysteine residues in VH and VL with the amino acid combination valine-alanine in both domains. Cysteine immunglobulin heavy chain variable region Homo sapiens
2 A fully functional cysteine-free derivative of the intrinsically stable anti-HER2 scFv fragment hu4D5-8 was generated by replacing the disulfide forming cysteine residues in VH and VL with the amino acid combination valine-alanine in both domains. Cysteine immunglobulin heavy chain variable region Homo sapiens