Pub. Date : 1998 Jun
PMID : 9616184
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Glucuronidation of amines and other xenobiotics catalyzed by expressed human UDP-glucuronosyltransferase 1A3. | Amines | UDP glucuronosyltransferase family 1 member A3 | Homo sapiens |
| 2 | We show that human UGT1A3, transiently expressed in human embryonic kidney 293 cells, also catalyzes the N-glucuronidation of primary, secondary, and tertiary amine substrates, such as 4-aminobiphenyl, diphenylamine, and cyproheptadine. | Amines | UDP glucuronosyltransferase family 1 member A3 | Homo sapiens |
| 3 | In contrast to expressed human UGT1A4, which catalyzes the glucuronidation of amines with high efficiency, glucuronidation of amines catalyzed by UGT1A3 exhibited low efficiency, suggesting that UGT1A3 makes only a limited contribution to the metabolic elimination of these compounds. | Amines | UDP glucuronosyltransferase family 1 member A3 | Homo sapiens |
| 4 | In contrast to expressed human UGT1A4, which catalyzes the glucuronidation of amines with high efficiency, glucuronidation of amines catalyzed by UGT1A3 exhibited low efficiency, suggesting that UGT1A3 makes only a limited contribution to the metabolic elimination of these compounds. | Amines | UDP glucuronosyltransferase family 1 member A3 | Homo sapiens |
| 5 | In addition to amines, expressed human UGT1A3 catalyzed the glucuronidation of opioids (e.g. morphine and buprenorphine), coumarins, flavonoids (e.g. naringenin and quercetin), anthraquinones, and small phenolic compounds (e.g. 4-nitrophenol). | Amines | UDP glucuronosyltransferase family 1 member A3 | Homo sapiens |