Title : Enhanced cytotoxicity of nucleoside analogs by overexpression of mitochondrial deoxyguanosine kinase in cancer cell lines.

Pub. Date : 1998 Jun 12

PMID : 9614068






2 Functional Relationships(s)
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1 We overexpressed dGK as a fusion protein to the green fluorescent protein in the human pancreatic cancer cell lines PanC-1 and MIA PaCa-2 to determine the importance of dGK-mediated nucleoside analog phosphorylation. Nucleosides Diacyl glycerol kinase Drosophila melanogaster
2 Our data imply that the dGK activity is rate-limiting for the efficacy of nucleoside analogs in the cell lines investigated. Nucleosides Diacyl glycerol kinase Drosophila melanogaster