Title : Upregulation of urokinase in alveolar macrophages and lung tissue in response to silica particles.

Pub. Date : 1998 Jun

PMID : 9609744






2 Functional Relationships(s)
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1 We found in both control and silica-treated animals that amiloride almost totally abolished PA activity in bronchoalveolar lavage (BAL) fluid (BALF), indicating that initial upregulation (from day 1) as well as sustained PA activity (up to day 30) observed in response to silica is related to changes in urokinase-type PA (uPA). Amiloride plasminogen activator, urokinase Mus musculus
2 We found in both control and silica-treated animals that amiloride almost totally abolished PA activity in bronchoalveolar lavage (BAL) fluid (BALF), indicating that initial upregulation (from day 1) as well as sustained PA activity (up to day 30) observed in response to silica is related to changes in urokinase-type PA (uPA). Amiloride plasminogen activator, urokinase Mus musculus