Title : Esterified cholesterol accumulation induced by aggregated LDL uptake in human vascular smooth muscle cells is reduced by HMG-CoA reductase inhibitors.

Pub. Date : 1998 May

PMID : 9598832






1 Functional Relationships(s)
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1 The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor simvastatin (5 micromol/L) reduced EC accumulation derived from agLDL uptake by 58% and 35% in platelet-derived growth factor-stimulated and unstimulated VSMCs, respectively. Cholesterol Esters 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens