Title : Improvement of repolarization abnormalities by a K+ channel opener in the LQT1 form of congenital long-QT syndrome.

Pub. Date : 1998 Apr 28

PMID : 9593563






2 Functional Relationships(s)
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1 BACKGROUND: This study used monophasic action potential (MAP) to examine the effect of nicorandil, a K+ channel opener, on repolarization abnormalities induced by epinephrine in the LQT1 form of congenital long-QT syndrome in which the KvLQT1 mutation underlies the defect in the channel responsible for the slowly activating component of the delayed rectifier potassium current. Epinephrine potassium voltage-gated channel subfamily Q member 1 Homo sapiens
2 In LQT1 patients, epinephrine infusion prolonged the QT interval and 90% MAP duration (MAPD90) and increased the dispersion of MAPD90. Epinephrine potassium voltage-gated channel subfamily Q member 1 Homo sapiens