Title : Pronostic and therapeutic consequences of Gs alpha mutations in somatotroph adenomas.

Pub. Date : 1998 May

PMID : 9589663






3 Functional Relationships(s)
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1 During the acute octreotide test, the GH nadir was significantly lower in the gsp-positive adenomas (85% of maximal inhibition vs. 52%). Octreotide GNAS complex locus Homo sapiens
2 Eighteen patients were treated with octreotide (300 micrograms/day) for at least 3 months before surgery: the percent inhibition of GH hypersecretion was higher in gsp-positive adenomas (76% vs. 47%). Octreotide GNAS complex locus Homo sapiens
3 In cell culture, the octreotide-induced inhibition of GH release was significantly higher in gsp-positive adenomas (71% vs. 30%). Octreotide GNAS complex locus Homo sapiens