Pub. Date : 1997 Nov 1
PMID : 9581570
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A tyrosine residue essential for catalytic activity in aminopeptidase A. | Tyrosine | glutamyl aminopeptidase | Mus musculus |
| 2 | Treatment of APA with N-acetylimidazole results in a loss of enzymic activity; this is prevented by the competitive aminopeptidase inhibitor amastatin, suggesting the presence of an important tyrosine, lysine or cysteine residue at the active site of APA. | Tyrosine | glutamyl aminopeptidase | Mus musculus |
| 3 | Furthermore sequence alignment of mouse APA with other monozinc aminopeptidases indicates the presence of a conserved tyrosine (Tyr-471 in APA). | Tyrosine | glutamyl aminopeptidase | Mus musculus |
| 4 | Furthermore sequence alignment of mouse APA with other monozinc aminopeptidases indicates the presence of a conserved tyrosine (Tyr-471 in APA). | Tyrosine | glutamyl aminopeptidase | Mus musculus |
| 5 | Furthermore sequence alignment of mouse APA with other monozinc aminopeptidases indicates the presence of a conserved tyrosine (Tyr-471 in APA). | Tyrosine | glutamyl aminopeptidase | Mus musculus |
| 6 | Furthermore sequence alignment of mouse APA with other monozinc aminopeptidases indicates the presence of a conserved tyrosine (Tyr-471 in APA). | Tyrosine | glutamyl aminopeptidase | Mus musculus |
| 7 | The functional role of Tyr-471 in APA was investigated by replacing this residue with a phenylalanine (Phe-471) or a histidine (His-471) residue by site-directed mutagenesis. | Tyrosine | glutamyl aminopeptidase | Mus musculus |