Title : Effects of N-methyl-D-aspartic acid and kainic acid on prolactin secretion in hyper- and hypoprolactinaemic conditions.

Pub. Date : 1998 Apr

PMID : 9578517






9 Functional Relationships(s)
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1 Effects of N-methyl-D-aspartic acid and kainic acid on prolactin secretion in hyper- and hypoprolactinaemic conditions. Kainic Acid prolactin Rattus norvegicus
2 OBJECTIVE: The stimulatory and inhibitory effects of N-methyl-D-aspartic acid (NMDA) and kainic acid on prolactin (PRL) secretion have been correlated with the serum prolactin concentrations before drug administration. Kainic Acid prolactin Rattus norvegicus
3 OBJECTIVE: The stimulatory and inhibitory effects of N-methyl-D-aspartic acid (NMDA) and kainic acid on prolactin (PRL) secretion have been correlated with the serum prolactin concentrations before drug administration. Kainic Acid prolactin Rattus norvegicus
4 OBJECTIVE: The stimulatory and inhibitory effects of N-methyl-D-aspartic acid (NMDA) and kainic acid on prolactin (PRL) secretion have been correlated with the serum prolactin concentrations before drug administration. Kainic Acid prolactin Rattus norvegicus
5 In the present experiments, we analysed the role of NMDA and kainic acid in PRL secretion in females with different serum concentrations of PRL. Kainic Acid prolactin Rattus norvegicus
6 (2) NMDA did not change PRL secretion in neonatally androgenized females, whereas NMDA and kainic acid inhibited PRL release in neonatally oestrogenized females. Kainic Acid prolactin Rattus norvegicus
7 (3) Kainic acid inhibited PRL secretion in prepubertal hyper- and hypoprolactinaemic rats. Kainic Acid prolactin Rattus norvegicus
8 (b) The stimulatory or inhibitory effects of NMDA and kainic acid on PRL secretion were not strictly related to basal PRL concentrations and necessarily involved a change in the secretion of prolactin releasing factors, as no correlations were observed between changes in pituitary concentrations of dopamine and serum PRL concentrations. Kainic Acid prolactin Rattus norvegicus
9 (d) NMDA and kainic acid blocked the mechanisms involved in stress-induced PRL secretion. Kainic Acid prolactin Rattus norvegicus