Title : IGF-I and insulin amplify IL-1 beta-induced nitric oxide and prostaglandin biosynthesis.

Pub. Date : 1998 Apr

PMID : 9575890






2 Functional Relationships(s)
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1 In our current studies, we determine whether insulin and IGF-I are involved in the signal transduction mechanisms resulting in IL-1 beta-induced NO and PGE2 biosynthesis in renal mesangial cells. Dinoprostone insulin like growth factor 1 Homo sapiens
2 We demonstrate that both insulin and IGF-I increase IL-1 beta-induced Cox-2 and iNOS protein expression, which in turn enhance PGE2 and NO production. Dinoprostone insulin like growth factor 1 Homo sapiens