Pub. Date : 1998 Jan
PMID : 9568379
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effects of hexamethonium, phenothiazines, propranolol and ephedrine on acetylcholinesterase carbamylation by physostigmine, aldicarb and carbaryl: interaction between the active site and the functionally distinct peripheral sites in acetylcholinesterase. | Physostigmine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 2 | Effects of hexamethonium, phenothiazines, propranolol and ephedrine on acetylcholinesterase carbamylation by physostigmine, aldicarb and carbaryl: interaction between the active site and the functionally distinct peripheral sites in acetylcholinesterase. | Physostigmine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 3 | Physostigmine, aldicarb and carbaryl were potent inhibitors of acetylcholinesterase (AChE). | Physostigmine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 4 | Physostigmine, aldicarb and carbaryl were potent inhibitors of acetylcholinesterase (AChE). | Physostigmine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 5 | The physostigmine-inhibited AChE fluoresced at 300 nm excitation and 500 nm emission wavelengths, but the aldicarb and carbaryl inhibited enzyme did not. | Physostigmine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 6 | The fluorescence intensity of physostigmine-inhibited AChE decreased with increasing the substrate (acetylthiocholine) concentration, thus indicating that physostigmine binding to the active site is essential for the development of fluorescence. | Physostigmine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 7 | The fluorescence intensity of physostigmine-inhibited AChE decreased with increasing the substrate (acetylthiocholine) concentration, thus indicating that physostigmine binding to the active site is essential for the development of fluorescence. | Physostigmine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 8 | Thus, the physostigmine-inhibited AChE fluoresces due to the binding of trimethylpyrrolo[2,3-b]indol (TMPI) moiety, formed by the hydrolysis of physostigmine, to a peripheral site in AChE. | Physostigmine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 9 | Thus, the physostigmine-inhibited AChE fluoresces due to the binding of trimethylpyrrolo[2,3-b]indol (TMPI) moiety, formed by the hydrolysis of physostigmine, to a peripheral site in AChE. | Physostigmine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 10 | Thus, the physostigmine-inhibited AChE fluoresces due to the binding of trimethylpyrrolo[2,3-b]indol (TMPI) moiety, formed by the hydrolysis of physostigmine, to a peripheral site in AChE. | Physostigmine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 11 | Thus, the physostigmine-inhibited AChE fluoresces due to the binding of trimethylpyrrolo[2,3-b]indol (TMPI) moiety, formed by the hydrolysis of physostigmine, to a peripheral site in AChE. | Physostigmine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 12 | Hexamethonium protected AChE from inhibition by carbamates and decreased the fluorescence intensity of the physostigmine-inhibited AChE. | Physostigmine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |