Pub. Date : 1998
PMID : 9564606
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Differential trace amine alterations in individuals receiving acetylenic inhibitors of MAO-A (clorgyline) or MAO-B (selegiline and pargyline). | Amines | monoamine oxidase B | Homo sapiens |
2 | In comparative studies with other, structurally similar acetylenic inhibitors of MAO, pargyline, an MAO-B > MAO-A inhibitor used in doses of 90 mg/day for three or more weeks, produced elevations in these trace amines which were similar to those found with the highest dose of selegiline studied. | Amines | monoamine oxidase B | Homo sapiens |
3 | Overall, trace amine elevations in individuals receiving the highest dose of deprenyl or receiving pargyline were approximately three to five-fold lower than the elevations observed in individuals lacking the genes for both MAO-A and MAO-B, suggesting that these drug doses yield incomplete inhibition of MAO-A and MAO-B. | Amines | monoamine oxidase B | Homo sapiens |