Title : Disruption of p53 function in immortalized human cells does not affect survival or apoptosis after taxol or vincristine treatment.

Pub. Date : 1998 Apr

PMID : 9563901






3 Functional Relationships(s)
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1 In the present study, we report our findings on the impact of p53 disruption on the sensitivity of human cell lines to the antimitotic agents Taxol and vincristine. Paclitaxel tumor protein p53 Homo sapiens
2 We also found that contrary to gamma-irradiation, Taxol and vincristine could induce apoptosis in lymphoma cell lines harboring p53 mutations. Paclitaxel tumor protein p53 Homo sapiens
3 The effect of p53 disruption on Taxol sensitivity was explored further in the breast carcinoma MCF-7 and colon carcinoma HCT-116 cell lines that had been stably transfected with either the human papillomavirus type-16 E6 gene or a dominant-negative mutant p53 gene. Paclitaxel tumor protein p53 Homo sapiens