Pub. Date : 1998 Apr
PMID : 9563901
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | In the present study, we report our findings on the impact of p53 disruption on the sensitivity of human cell lines to the antimitotic agents Taxol and vincristine. | Paclitaxel | tumor protein p53 | Homo sapiens |
2 | We also found that contrary to gamma-irradiation, Taxol and vincristine could induce apoptosis in lymphoma cell lines harboring p53 mutations. | Paclitaxel | tumor protein p53 | Homo sapiens |
3 | The effect of p53 disruption on Taxol sensitivity was explored further in the breast carcinoma MCF-7 and colon carcinoma HCT-116 cell lines that had been stably transfected with either the human papillomavirus type-16 E6 gene or a dominant-negative mutant p53 gene. | Paclitaxel | tumor protein p53 | Homo sapiens |