Title : Adenovirus-mediated p53 gene therapy and paclitaxel have synergistic efficacy in models of human head and neck, ovarian, prostate, and breast cancer.

Pub. Date : 1998 Apr

PMID : 9563876






3 Functional Relationships(s)
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1 In the p53null SK-OV-3 xenograft model of ovarian cancer, a dosing schedule of p53 Ad that, by itself, had a relatively minimal effect on tumor burden (16%) caused a much greater decrease in tumor burden (55%) when combined with paclitaxel. Paclitaxel tumor protein p53 Homo sapiens
2 In the p53null SK-OV-3 xenograft model of ovarian cancer, a dosing schedule of p53 Ad that, by itself, had a relatively minimal effect on tumor burden (16%) caused a much greater decrease in tumor burden (55%) when combined with paclitaxel. Paclitaxel tumor protein p53 Homo sapiens
3 In summary, p53 Ad for cancer shows enhanced efficacy when combined with paclitaxel. Paclitaxel tumor protein p53 Homo sapiens