Title : Lack of CYP3A inhibition effects of sertindole on terfenadine in healthy volunteers.

Pub. Date : 1998 Mar

PMID : 9562230






2 Functional Relationships(s)
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1 Although terfenadine is a substrate for CYP3A (cytochrome P-450 3A), while sertindole is a substrate for both CYP2D6 and CYP3A4, the results in this study suggest that sertindole, at a clinical dose, is not an inhibitor of the metabolism of terfenadine. sertindole cytochrome P450 family 2 subfamily D member 6 Homo sapiens
2 Although terfenadine is a substrate for CYP3A (cytochrome P-450 3A), while sertindole is a substrate for both CYP2D6 and CYP3A4, the results in this study suggest that sertindole, at a clinical dose, is not an inhibitor of the metabolism of terfenadine. sertindole cytochrome P450 family 2 subfamily D member 6 Homo sapiens