Title : Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalities.

Pub. Date : 1998 Apr 28

PMID : 9560283






1 Functional Relationships(s)
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1 Homozygous mutants (Npt2(-/-)) exhibit increased urinary Pi excretion, hypophosphatemia, an appropriate elevation in the serum concentration of 1,25-dihydroxyvitamin D with attendant hypercalcemia, hypercalciuria and decreased serum parathyroid hormone levels, and increased serum alkaline phosphatase activity. 1,25-dihydroxyvitamin D solute carrier family 34 (sodium phosphate), member 1 Mus musculus