Pub. Date : 1998 May 1
PMID : 9556603
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Differentiation of glycine antagonist sites of N-methyl-D-aspartate receptor subtypes. | Glycine | glutamate ionotropic receptor NMDA type subunit 1 L homeolog | Xenopus laevis |
2 | The binding site for the co-agonist glycine on N-methyl-D-aspartate (NMDA) receptors has been mapped to the NR1 subunit whereas binding of the principal agonist glutamate is mediated by the NR2 subunits. | Glycine | glutamate ionotropic receptor NMDA type subunit 1 L homeolog | Xenopus laevis |
3 | Using the novel glycine site antagonist and photoaffinity label CGP 61594, distinct contributions of the NR2 subunit variants to the glycine antagonist binding domains of NMDA receptor subtypes are demonstrated. | Glycine | glutamate ionotropic receptor NMDA type subunit 1 L homeolog | Xenopus laevis |
4 | Using the novel glycine site antagonist and photoaffinity label CGP 61594, distinct contributions of the NR2 subunit variants to the glycine antagonist binding domains of NMDA receptor subtypes are demonstrated. | Glycine | glutamate ionotropic receptor NMDA type subunit 1 L homeolog | Xenopus laevis |
5 | Thus, [3H]CGP 61594 is the first antagonist radioligand that reliably distinguishes the glycine site of NMDA receptor subtypes. | Glycine | glutamate ionotropic receptor NMDA type subunit 1 L homeolog | Xenopus laevis |
6 | [3H]CGP 61594 is a promising tool to identify the NR2 subunit domains that contribute to differential glycine antagonist sites of NMDA receptor subtypes. | Glycine | glutamate ionotropic receptor NMDA type subunit 1 L homeolog | Xenopus laevis |