Title : Differentiation of glycine antagonist sites of N-methyl-D-aspartate receptor subtypes. Preferential interaction of CGP 61594 with NR1/2B receptors.

Pub. Date : 1998 May 1

PMID : 9556603






6 Functional Relationships(s)
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1 Differentiation of glycine antagonist sites of N-methyl-D-aspartate receptor subtypes. Glycine glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis
2 The binding site for the co-agonist glycine on N-methyl-D-aspartate (NMDA) receptors has been mapped to the NR1 subunit whereas binding of the principal agonist glutamate is mediated by the NR2 subunits. Glycine glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis
3 Using the novel glycine site antagonist and photoaffinity label CGP 61594, distinct contributions of the NR2 subunit variants to the glycine antagonist binding domains of NMDA receptor subtypes are demonstrated. Glycine glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis
4 Using the novel glycine site antagonist and photoaffinity label CGP 61594, distinct contributions of the NR2 subunit variants to the glycine antagonist binding domains of NMDA receptor subtypes are demonstrated. Glycine glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis
5 Thus, [3H]CGP 61594 is the first antagonist radioligand that reliably distinguishes the glycine site of NMDA receptor subtypes. Glycine glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis
6 [3H]CGP 61594 is a promising tool to identify the NR2 subunit domains that contribute to differential glycine antagonist sites of NMDA receptor subtypes. Glycine glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis