Title : Peroxynitrite increases the degradation of aconitase and other cellular proteins by proteasome.

Pub. Date : 1998 May 1

PMID : 9556559






2 Functional Relationships(s)
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1 We report that exposure of aconitase to moderate concentrations of peroxynitrite, 3-morpholinosydnonimine (SIN-1; a superoxide- and nitric oxide-liberating substance), or hydrogen peroxide, inhibits the enzyme and enhances susceptibility to proteolytic digestion by the isolated 20 S proteasome. Superoxides MAPK associated protein 1 Homo sapiens
2 It should be noted that the superoxide and nitric oxide liberated by SIN-1 decomposition react to form a steady flux of peroxynitrite. Superoxides MAPK associated protein 1 Homo sapiens