Title : Co-injection of beta-amyloid with ibotenic acid induces synergistic loss of rat hippocampal neurons.

Pub. Date : 1998 May

PMID : 9539218






1 Functional Relationships(s)
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1 Although beta-amyloid alone or ibotenic acid alone exerted only minimal degenerating effects on neurons just around the injection site, the co-injection of beta-amyloid 1-40 or beta-amyloid 25-35 with ibotenic acid produced drastic neuronal loss; the haematoxylin-eosin staining revealed that most neurons not only around the injection site but also in distant areas including CA1, CA4 and dentate gyrus were depleted. Ibotenic Acid carbonic anhydrase 1 Rattus norvegicus