Pub. Date : 1998 Jan
PMID : 9522034
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Radioligand displacement assay was performed to characterize the selectivity of loxiglumide to CCK-A (cholecystokinin-A) receptor (rat pancreas and bovine gallbladder) and CCK-B/gastrin receptors (guinea pig cerebral cortex and guinea pig gastric parietal cell). | loxiglumide | cholecystokinin | Cavia porcellus |
| 2 | Loxiglumide inhibited 125I-CCK-8 binding to rat pancreatic and bovine gallbladder membranes with IC50 values of 195 and 77.1 nmol/l, respectively. | loxiglumide | cholecystokinin | Cavia porcellus |
| 3 | Loxiglumide also inhibited 125I-CCK-8 binding to guinea pig cerebral cortex membranes and parietal cells with IC50 values of 12363 and 15455 nmol/l, respectively. | loxiglumide | cholecystokinin | Cavia porcellus |
| 4 | These results indicate that the affinity of loxiglumide to CCK-A receptor is at least 63 times greater than that to CCK-B/gastrin receptors. | loxiglumide | cholecystokinin | Cavia porcellus |
| 5 | In vitro functional studies utilizing CCK-induced contractions of the isolated guinea pig gallbladder and ileum further demonstrate that loxiglumide acts as a competitive CCK antagonist with a high affinity to these tissues (gallbladder, pA2:6.71). | loxiglumide | cholecystokinin | Cavia porcellus |
| 6 | In vitro functional studies utilizing CCK-induced contractions of the isolated guinea pig gallbladder and ileum further demonstrate that loxiglumide acts as a competitive CCK antagonist with a high affinity to these tissues (gallbladder, pA2:6.71). | loxiglumide | cholecystokinin | Cavia porcellus |