Title : Fluorescent probing with felodipine of the dihydropyridine receptor and its interaction with the ryanodine receptor calcium release channel.

Pub. Date : 1998 Mar 17

PMID : 9514900






1 Functional Relationships(s)
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1 The fluorescence enhancement was due to the binding of felodipine to high-affinity (Kd"s of 0.35 and 1.25 nM in cardiac SLM and skeletal SR, respectively) 1,4-dihydropyridine sites of the dihydropyridine receptor (DHPR), as evidenced in competition experiments with the DHP analog isradipine. Isradipine calcium voltage-gated channel subunit alpha1 S Homo sapiens