Title : Compensatory responses to inhibition of hepatic squalene synthase.

Pub. Date : 1998 Mar 15

PMID : 9514656






1 Functional Relationships(s)
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1 The mechanism by which depletion of hepatic cholesterol levels, achieved by inhibition of squalene synthase, alters hepatic LDL receptor, HMG-CoA reductase, and cholesterol 7alpha-hydroxylase gene expression was investigated by measuring transcription rates, mRNA stability, rates of translation, translational efficiency, and levels of sterol response element binding proteins. Sterols farnesyl-diphosphate farnesyltransferase 1 Homo sapiens