Title : Expression and characterization of dog CYP2D15 using baculovirus expression system.

Pub. Date : 1998 Jan

PMID : 9504424






2 Functional Relationships(s)
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1 Although the expressed dog CYP2D15 showed high catalytic activity for the hydroxylations of bunitrolol and imipramine at low substrate concentration (10 microM), the catalytic activity for that of debrisoquine (50 microM) was extremely low as compared with that of CYP2D from other species. bunitrolol cytochrome P450 2D15 Canis lupus familiaris
2 Although the expressed dog CYP2D15 showed high catalytic activity for the hydroxylations of bunitrolol and imipramine at low substrate concentration (10 microM), the catalytic activity for that of debrisoquine (50 microM) was extremely low as compared with that of CYP2D from other species. bunitrolol cytochrome P450 2D15 Canis lupus familiaris