Title : Stretch activates Jun N-terminal kinase/stress-activated protein kinase in vascular smooth muscle cells through mechanisms involving autocrine ATP stimulation of purinoceptors.

Pub. Date : 1998 Mar 13

PMID : 9497362






2 Functional Relationships(s)
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1 The stretch-induced activation JNK/SAPK is attenuated by the addition of hexokinase or apyrase that scavenge ATP in media. Adenosine Triphosphate mitogen-activated protein kinase 9 Homo sapiens
2 These results indicate that stretch activates JNK/SAPK in vascular smooth muscle cells through mechanisms involving autocrine stimulation of purinoceptors by ATP and its hydrolyzed product adenosine. Adenosine Triphosphate mitogen-activated protein kinase 9 Homo sapiens