Title : Streptozotocin-induced diabetes enhances cardiac heparin-releasable lipoprotein lipase activity in spontaneously hypertensive rats.

Pub. Date : 1998 Mar

PMID : 9495276






5 Functional Relationships(s)
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1 Heparin perfusion of the isolated Langendorff heart induced the release of LPL activity. Heparin lipoprotein lipase Rattus norvegicus
2 However, induction of streptozotocin-induced diabetes in SHR, as in Wistar rats, increased peak heparin-releasable LPL activity in perfused hearts. Heparin lipoprotein lipase Rattus norvegicus
3 The elevated heparin-releasable LPL peak could not be accounted for by enhanced LPL synthesis in that both cellular and surface-bound LPL activities in myocytes from SHR-diabetic rats were low relative to control. Heparin lipoprotein lipase Rattus norvegicus
4 Chronic (12-day) insulin treatment of SHR-diabetic rats reduced the augmented heparin-releasable LPL activity and increased cell-associated LPL activity. Heparin lipoprotein lipase Rattus norvegicus
5 Moreover, acute (90-minute) treatment of SHR-diabetic rats with rapid-acting insulin also reduced the heparin-releasable LPL activity to normal, although it had no effect on the low cellular LPL activity. Heparin lipoprotein lipase Rattus norvegicus