Pub. Date : 1998 Jan 15
PMID : 9493268
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The pH dependence of IgG binding to FcRn can therefore primarily be attributed to titration of histidine residues on Fc that interact with anionic pockets on the receptor. | Histidine | Fc gamma receptor and transporter | Homo sapiens |
| 2 | The FcRn dimer, which is required for high affinity binding of IgG, is itself stabilized at acidic pH by histidine-mediated salt bridges and a sidechain rearrangement that creates a more favorable interaction with an anionic pocket at pH 6.5 relative to pH 8. | Histidine | Fc gamma receptor and transporter | Homo sapiens |