Title : Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia.

Pub. Date : 1998 Feb 19

PMID : 9486655






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 PLZF-RARalpha contains a second, RA-resistant binding site in the PLZF amino-terminal region. Tretinoin zinc finger and BTB domain containing 16 Homo sapiens
2 PLZF-RARalpha contains a second, RA-resistant binding site in the PLZF amino-terminal region. Tretinoin zinc finger and BTB domain containing 16 Homo sapiens
3 Therefore, recruitment of histone deacetylase is crucial to the transforming potential of APL fusion proteins, and the different effects of RA on the stability of the PML-RARalpha and PLZF-RARalpha co-repressor complexes determines the differential response of APLs to RA. Tretinoin zinc finger and BTB domain containing 16 Homo sapiens