Title : Protein tyrosine phosphorylation mediates TNF-induced endothelial-neutrophil adhesion in vitro.

Pub. Date : 1998 Feb

PMID : 9486255






2 Functional Relationships(s)
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1 Time- and dose-dependent TNF-alpha-stimulated ICAM-1 and E-selectin upregulation and neutrophil adhesion each were suppressed by tyrosine kinase inhibitors, including genistein (200 microM), but not genistein, its isoflavone analog without tyrosine kinase inhibitory activity. Genistein tumor necrosis factor Homo sapiens
2 Tyrosine phosphorylation of two proteins (85 and 145 kDa in the cytoskeleton fraction) found minutes after TNF-alpha-stimulation was also inhibited by genistein. Genistein tumor necrosis factor Homo sapiens